BioAdvanced All-in-One Rose & Flower Care granules is convenient, easy-to-use and takes the guesswork out of application. It is three systemic products in one: fertilizer, insect control and disease control. All-In-One Rose & Flower Care is easy to use and requires no spraying! Systemic formula cannot be washed off by rain. Use it to protect your roses and flowers from Aphids, Caterpillars, Black Spot, Powdery Mildew, Rust, Southern Blight and other listed insects and diseases for up to 6 weeks. BioAdvanced. Get More From The Blue Bottle?.